A high Hct level has been shown to be associated with an increased risk of cardiovascular disease 1, 2, 3. Hematocrit (Hct), the volume percentage of red blood cells (RBCs) in total blood, and hemoglobin (Hb) are associated with a risk of cardiovascular disease. Increases in the levels of Hct, Hb and RBCs within normal ranges may have beneficial effects on the vasculature. Low and high levels of Hct, Hb and RBCs were associated with vascular smooth muscle dysfunction, and low Hct levels were associated with abnormal vascular structure. Similar results were obtained for Hb and RBCs. Adjusted odds ratio of being in the low tertile of brachial IMT was significantly lower in the < 39.9% Hct groups. The adjusted odds ratio of being in the low tertile of NID was significantly higher in the < 42.9% and ≥ 49.0% Hct groups. We used 46.0–48.9% Hct as a reference to define the lower tertile.
There were no significant differences in FMD and baPWV among the six groups. Brachial IMT was lowest in the 46.0–48.9% Hct group among the six groups. NID was highest in the 46.0–48.9% Hct group among the six groups according to Hct levels. The subjects were divided into six groups according to the levels of Hct, Hb and RBCs. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced vasodilation (NID), brachial intima media thickness (IMT), and brachial-ankle pulse wave velocity (baPWV) in 807 men.
The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease.
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